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Dr. Chittur V Srikanth

Professor
E-mail: cvsrikanth at rcb dot res dot in

  • PhD 2005, Institute of Microbial Technology
  • Postdoc at Harvard Medical School, USA & University of Massachusetts Medical School, USA
  • Professor

Research in my lab is broadly directed at understanding the key events that cause inflammation during infections and autoimmune disorders of gastrointestinal tract. Specifically, we work on very important human diseases which arise due to bacterial infections and immune disorders. Our key interests are: (i) Host-Salmonella crosstalk, (ii) Persistent Salmonella infections, (iii) Gut microbiota and its connection to human diseases, (iv) Intestinal autoimmune disorders, (v) Molecular mechanisms of colorectal cancer and gallbladder cancer.

We focus on model bacterial pathogen Salmonella Typhimurium with an ultimate goal to understand molecular mechanisms underlying its pathogenesis. The gram negative, facultative intracellular bacterial pathogen Salmonella is one of the most frequent causes of acute gastroenteritis in humans. The disease results from a complex cascade of interactions between the pathogenic bacterium, the host intestinal epithelium, the commensal microbiota and the immune system of the host. Each of these entities are of interest to us. The disease manifestation is characterized histologically by massive infiltration of neutrophils (PMN), a phenotype also observed in some of the chronic autoimmune diseases of the gut such as Crohn’s disease (CD) and ulcerative colitis (UC). In the recent times, there has been a sudden increase in incidence of CD and UC.

Crohn’s disease (CD) and ulcerative colitis (UC) are serious autoimmune disorders which are now on a rise. Uncontrolled inflammation contributes to the pathogenesis of inflammatory diseases as well as the development of cancers. We are also working on inflammation induced gastrointestinal cancers.

Using state of the art tools of microbiology, molecular biology and fluorescent-imaging and proteomics, our group probes complex mechanisms operational during these illnesses. We utilise cell culture model , murine model(s), organotypic models and human patient samples to carry out these investigations. We have long standing collaborations with clinicians and experts in the field which has allowed us to create our own niche in the field. We have been examining the involvement of post-tranlational modification (PTMs) pathways in shaping inflammatory processes of gut. Our recent paradigm shifting discovery, demonstrating the critical role of SUMOylaiton in modulation of gut homeostasis has opened up several exciting avenues in biology of infectious diseases and GI illnesses. In future, we aim to dissect the precise role of PTM pathways in governing epithelial-immune crosstalk particularly in the context of intestinal inflammation. The ultimate goal is not only to combat bacterial pathogenesis but also find therapeutic solutions to auto-immune disorders.

  • Wellcome-DBT Intermediate Fellow
  • Mr. Rohan Babar
    Persuing PhD: Senior Research Fellow
    rohan.babar@rcb.res.in
  • Ms. Yesheswini Rajendran
    Persuing PhD: Senior Research Fellow
    yesheswini.rajendran@rcb.res.in
  • Ms. Kirti Kajal
    Persuing PhD: Junior Research Fellow
    kirti.kajal@rcb.res.in
  • Mr. Vishal Madanlal Angnani
    Persuing PhD: Junior Research Fellow
    vishal.angnani@rcb.res.in
  • Ms. Poorvi Saini
    Persuing PhD: Junior Research Fellow
    poorvi.saini@rcb.res.in
  • Ms. Vidhu Chandrika
    Persuing PhD: Junior Research Fellow
    vidhu.chandrika@rcb.res.in
  • Ms. Komal Kharetta
    Project Junior Research Fellow
    komal.kharetta@rcb.res.in
  • Mr. Irzam Haroon
    Project Fellow
    irzamharoon@rcb.res.in
  • Ms. Neha Gulia
    Masters Dissertation Student
    neha.gulia@rcb.res.in
  • Smt.Kusum P Lab Attendant
  • Lab Alumni

  • Dr. Gayatree Mohapatra
    Current affiliation: Wiesman Institute of Science, Israel
    Email: gayatree.mohapatra@wiesman.ac.il
  • Dr Salman Mustfa Ahmad
    Current Affiliation: AstraZeneka, United Kingdon
    Email: salman.mustfa@astrazeneca.com
  • Dr. Sarika Rana
    Current Affiliation: Laboratory of Immunobiology, Universite ́ Libre de Bruxelles, Gosselies, Belgium
    Email: sarika.rana21@gmail.com
  • Dr Aamiar Suhail
    Current Affiliation: Harvard Medical School USA
    Email: suhail.aamir0890@gmail.com
  • Dr. Pharvendra Kumar
    Current Affiliation: Umass Medical School, Worcester USA
    Email: pharverndra.k@rcb.res.in
  • Dr. Preksha Gaur
    Current Affiliation: Harvard Medical School USA
    Email: prekshagaur30@gmail.com
  • Dr. Sonalika Maurya
    Current Affiliation: Regional Centre for Biotechnology, Faridabad
    Email: bo12m1007@iith.ac.in
  • Dr. Hridya Chandrasekhar
    Current Affiliation: Regional Centre for Biotechnology, Faridabad
    Email: hridya@rcb.res.in
  • Wellcome-DBT Intermediate Fellow
  • Dr. Mukesh Kumar
    Post Doctoral fellow under Wellcome Trust DBT IA Grant
    mukeshsingh@rcb.res.in
  • Dr. Prabhakar
    Young Investigator
    prabhakar@rcb.res.in
  • Dr. Smriti Verma
    Young Investigator
    smriti@rcb.ac.in
  • Dr. Sunil Kumar
    Post Doctoral fellow under Wellcome Trust DBT IA Grant
    Skumar244@gmail.com
  • S Nandha Kumar
    snandha.kumar@rcb.res.in
  • Dikshalee Bassi
    dikshaleebassi@gmail.com
  • Ezhuthachan Vishnu Askok Kumar
    vishnuashokkumarrcb@gmail.com
  • Dr. Swati Jain
    snandha.kumar@rcb.res.in
  • Dr. Preety Bajwa
    preetybwj25@gmail.com
  • Dr. Navneet Kaur Suhal
    neetu.lor@gmail.com
  • Ms Neha Yadav
    Neha.yadav@gmail.com
  • Ms Garima Chamoli
    Garima.chamoli2@gmail.com
  • Mr Pappu Bharti
    Lab Attendant
  1. Chandrasekhar H, Mohapatra G, Kajal K, Singh M, Walia K, Rana S, Kaur N, Sharma S, Tuli A, Das P, Srikanth CV. SifA SUMOylation governs Salmonella Typhimurium intracellular survival via modulation of lysosomal function. PLoS Pathog. 2023 Sep 29;19(9):e1011686.
  2. Markandey M, Bajaj A, Verma M, Virmani S, Singh MK, Gaur P, Das P, Srikanth CV, Makharia G, Kedia S, Ahuja V. Fecal microbiota transplantation refurbishes the crypt-associated microbiota in ulcerative colitis. iScience. 2023 Apr 23;26(5):106738.
  3. Mehrotra T, Konar D, Pragasam AK, Kumar S, Jana P, Babele P, Paul D, Purohit A, Tanwar S, Bakshi S, Das S, Verma J, Talukdar D, Narendrakumar L, Kothidar A, Karmakar SP, Chaudhuri S, Pal S, Jain K, Srikanth CV, Sankar MJ, Atmakuri K, Agarwal R, Gaind R, Ballal M, Kammili N, Bhadra RK, Ramamurthy T, Nair GB, Das B. Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2305465120.
  4. Gaur P, Rajendran Y, Srivastava B, Markandey M, Fishbain-Yoskovitz V, Mohapatra G, Suhail A, Chaudhary S, Tyagi S, Yadav SC, Pandey AK, Merbl Y, Bajaj A, Ahuja V, Srikanth C. Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis. Elife. 2024 Apr 9;12:RP89776.
  5. Verma P, Srivastava A, Srikanth CV, Bajaj A. Nanoparticle-mediated gene therapy strategies for mitigating inflammatory bowel disease. Biomater Sci. 2021 Mar 10;9(5):1481-1502.
  6. Rana S, Maurya S, Mohapatra G, Singh S, Babar R, Chandrasekhar H, Chamoli G, Rathore D, Kshetrapal P, Srikanth CV. Activation of epigenetic regulator KDM6B by Salmonella Typhimurium enables chronic infections. Gut Microbes. 2021 JanDec;13(1):1986665. Page 2 of 6
  7. Rana S, Maurya S, Chadrasekhar H, Srikanth CV. Molecular determinants of peaceful coexistence versus invasiveness of non-Typhoidal Salmonella: Implications in long-term side-effects. Mol Aspects Med. 2021 Oct;81:100997.
  8. Verma P, Srivastava A, Srikanth CV, Bajaj A. Nanoparticle-mediated gene therapy strategies for mitigating inflammatory bowel disease. Biomater Sci. 2021 Mar 10;9(5):1481-1502.
  9. Preksha G, Yesheswini R, Srikanth CV. Cell culture techniques in gastrointestinal research: Methods, possibilities and challenges. Indian J Pathol Microbiol. 2021 10: Awasthi A, Nain V, Srikanth CV, Puria R. A regulatory circuit between lncRNA and TOR directs amino acid uptake in yeast. Biochim Biophys Acta Mol Cell Res. 2020 Jun;1867(6):118680. 6: Aamir Suhail; zaigham abbas Rizvi; Prabhakar M; Syed Azmal Ali; Preksha G
  10. Awasthi A, Nain V, Srikanth CV, Puria R. A regulatory circuit between lncRNA and TOR directs amino acid uptake in yeast. Biochim Biophys Acta Mol Cell Res. 2020 Jun;1867(6):118680. 6: Aamir Suhail; zaigham abbas Rizvi; Prabhakar M; Syed Azmal Ali; Preksha G
  11. Kumar P, Soory A, Mustfa SA, Sarmah DT, Devvanshi H, Chatterjee S, Bossis G, Ratnaparkhi GS, Srikanth CV. Bidirectional regulation between AP-1 and SUMOylation pathway genes modulates inflammatory signaling during Salmonella infection. J Cell Sci. 2022 Aug 15;135(16):jcs260096.
  12. Aamir Suhail; zaigham abbas Rizvi; Prabhakar M; Syed Azmal Ali; Preksha Gaur; Mukesh Singh; Vineet Ahuja; Amit Awasthi; Chittur Srikanth. DeSUMOylase SENP7 mediated epithelial signalling triggers intestinal inflammation via expansion of Gamma-delta T cell. Cell Reports, Dec 2019
  13. Yavvari PS, Verma P, Mustfa SA, Pal S, Kumar S, Awasthi AK, Ahuja V, Srikanth CV*, Srivastava A*, Bajaj A*. A nanogel based oral gene delivery system targeting SUMOylation machinery to combat gut inflammation. Nanoscale. 2019 Mar 14;11(11):4970-4986. * co-corresponding authors.
  14. Yadav K, Yavvari PS, Pal S, Kumar S, Mishra D, Gupta S, Mitra M, Soni V, Khare N, Sharma P, Srikanth CV, Kapil A, Singh A, Nandicoori VK, Bajaj A. Oral Delivery of Cholic Acid-Derived Amphiphile Helps in Combating Salmonella-Mediated Gut Infection and Inflammation. Bioconjug Chem. 2019 Mar 20;30(3):721-732.
  15. Mohapatra G, Gaur P, Mujagond P, Singh M, Rana S, Pratap S, Kaur N, Verma S, Krishnan V, Singh N, Srikanth CV. A SUMOylation-dependent switch of RAB7 governs intracellular life and pathogenesis of Salmonella Typhimurium. J Cell Sci. 2019 Jan 11;132(1).
  16. Awasthi A, Kumar P, Srikanth CV, Sahi S, Puria R. Invitro Evaluation of Torin2 and 2, 6-Dihydroxyacetophenone in Colorectal Cancer Therapy. Pathol Oncol Res. 2019 Jan;25(1):301-309.
  17. Mustfa SA, Singh M, Suhail A, Mohapatra G, Verma S, Chakravorty D, Rana S, Rampal R, Dhar A, Saha S, Ahuja V, Srikanth CV. SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease. Open Biol. 2017 Jun;7(6).
  18. Srikanth CV, Verma S. Sumoylation as an Integral Mechanism in Bacterial Infection and Disease Progression. Adv Exp Med Biol. 2017;963:389-408.
  19. Verma S, Srikanth CV. Understanding the complexities of Salmonella-host crosstalk as revealed by in vivo model organisms. IUBMB Life. 2015 Jul;67(7):482-97. doi: 10.1002/iub.1393. Epub 2015 Jul 15. Review.
  20. Verma S, Mohapatra G, Ahmad SM, Rana S, Jain S, Khalsa JK, Srikanth CV. Salmonella Engages Host MicroRNAs To Modulate SUMOylation: a New Arsenal for Intracellular Survival. Mol Cell Biol. 2015 Sep 1;35(17):2932-46.
  21. Hallstrom KN, Srikanth CV, Agbor TA, Dumont CM, Peters KN, Paraoan L, Casanova JE, Boll EJ, McCormick BA. PERP, a host tetraspanning membrane protein, is required for Salmonella-induced inflammation. Cell Microbiol. 2015 Jun;17(6):843-59.
  22. Srikanth CV, Mercado-Lubo R, Hallstrom K, McCormick BA. Salmonella effector proteins and host-cell responses. Cell Mol Life Sci. 2011 Nov;68(22):3687-97.
  23. Wall DM, Srikanth CV, McCormick BA. Targeting tumors with salmonella Typhimurium- potential for therapy. Oncotarget. 2010 Dec;1(8):721-8. Review.
  24. Srikanth CV, Wall DM, Maldonado-Contreras A, Shi H, Zhou D, Demma Z, Mumy KL, McCormick BA. Salmonella pathogenesis and processing of secreted effectors by caspase-3. Science. 2010 Oct 15;330(6002):390-393.
  25. Johnson EE, Srikanth CV, Sandgren A, Harrington L, Trebicka E, Wang L, Borregaard N, Murray M, Cherayil BJ. Siderocalin inhibits the intracellular replication of Mycobacterium tuberculosis in macrophages. FEMS Immunol Med Microbiol. 2010 Feb;58(1):138-45.
  26. Kumar CM, Khare G, Srikanth CV, Tyagi AK, Sardesai AA, Mande SC. Facilitated oligomerization of mycobacterial GroEL: evidence for phosphorylation-mediated oligomerization. J Bacteriol. 2009 Nov;191(21):6525-38.
  27. Kaur J, Srikanth CV, Bachhawat AK. Differential roles played by the native cysteine residues of the yeast glutathione transporter, Hgt1p. FEMS Yeast Res. 2009 Sep;9(6):849-66.
  28. Harrington L, Srikanth CV, Antony R, Rhee SJ, Mellor AL, Shi HN, Cherayil BJ. Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitis. Infect Immun. 2008 Jul;76(7):3045-53.
  29. Srikanth CV, McCormick BA. Interactions of the intestinal epithelium with the pathogen and the indigenous microbiota: a three-way crosstalk. Interdiscip Perspect Infect Dis. 2008;2008:626827.
  30. Harrington L, Srikanth CV, Antony R, Shi HN, Cherayil BJ. A role for natural killer cells in intestinal inflammation caused by infection with Salmonella enterica serovar Typhimurium. FEMS Immunol Med Microbiol. 2007 Nov;51(2):372-80.
  31. Srikanth CV, Cherayil BJ. Intestinal innate immunity and the pathogenesis of Salmonella enteritis. Immunol Res. 2007;37(1):61-78.
  32. Srikanth CV, Vats P, Bourbouloux A, Delrot S, Bachhawat AK. Multiple cis-regulatory elements and the yeast sulphur regulatory network are required for the regulation of the yeast glutathione transporter, Hgt1p. Curr Genet. 2005 Jun;47(6):345-58.
  33. Srikanth CV, Chakraborti AK, Bachhawat AK. Acetaminophen toxicity and resistance in the yeast Saccharomyces cerevisiae. Microbiology. 2005 Jan;151(Pt 1):99-111
  34. Kohli DK, Srikanth CV, Bachhawat AK. A search tool for identification and analysis of conserved sequence patterns in Saccharomyces spp. orthologous promoter. In Silico Biol. 2004;4(4):411-5.
  35. Zhang MY, Bourbouloux A, Cagnac O, Srikanth CV, Rentsch D, Bachhawat AK, Delrot S. A novel family of transporters mediating the transport of glutathione derivatives in plants. Plant Physiol. 2004 Jan;134(1):482-91.
  36. Ganguly D, Srikanth CV, Kumar C, Vats P, Bachhawat AK. Why is glutathione (a tripeptide) synthesized by specific enzymes while TSH releasing hormone (TRH or thyroliberin), also a tripeptide, is produced as part of a prohormone protein? IUBMB Life. 2003 Sep;55(9):553-4..

Dr. Chittur V Srikanth
Professor
Regional Centre for Biotechnology
NCR Biotech Science Cluster
3rd Milestone, Faridabad-Gurgaon Expressway
P.O. Box No. 3, Faridabad - 121 001
Haryana (NCR Delhi), India
E-mail: cvsrikanth at rcb dot res dot in
Phone: 91 129-2848820

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