Research Highlights | Regional Centre for Biotechnology

Research Highlights

Research Highlights

Photograph of two uprooted young plants placed on a dark background, shown with intact shoots and root systems for comparison.

A method to identify DNA sequences flanking retrotransposon insertion sites in chickpea

Schematic illustration of pancreatic cancer showing a regulatory loop driven by epigenetics. Epigenetics-driven differential transcription upregulates NFAT2, leading to transcriptional upregulation of the calcium channel Orai3 at the plasma membrane, while March8 promotes lysosomal degradation.

One Factor, Two Fates: How NFATc1 Controls Orai3 in Pancreatic Cancer

Schematic illustration of a drug-loaded implant releasing a doxorubicin–STING agonist conjugate. The implant enables sustained delivery in mice—up to 4 months in the brain and 8 months via subcutaneous administration.

Long-lasting Hydrogel Mitigates Tumour Regression

Schematic diagram illustrating two pathways of Ataxin-3 aggregation as PolyQ length increases.

Decoding Ataxin-3 Phase Behavior in Spinocerebellar Ataxia Type 3

A scientific schematic illustrating the σ²⁸–FlgM complex and its transition to an open promoter complex. On the left, σ²⁸ is shown bound to the FlgM protein as a compact complex.

Unlocking the late flagellar gene synthesis in Pseudomonas aeruginosa

Composite figure illustrating the role of the SUN protein in plant immunity. Top panels show fluorescent microscopy images of PsSUN-RFP (magenta), PNET2B-GFP (green), and their merged signal, indicating co-localization.

An inner nuclear membrane protein links nuclear shape and plant stress responses

Circular schematic illustrating the multifunctional therapeutic roles of Amphiphile 1. The central structure shows the chemical structure of Amphiphile 1, surrounded by four labeled segments depicting its biological activities: membrane permeabilization, eradication of polymicrobial biofilms, resolution of inflammation, and wound care management.

Aspirin-Conjugated Cholic Acid Derivative Combats Polymicrobial Infections and Inflammation

The illustration depicts the RICTOR–UGCG axis as a control circuit that rewires cancer cell metabolism. Activated RICTOR disrupts epigenetic regulators to boost UGCG-driven GD3 ganglioside production, which in turn hyperactivates EGFR signalling. Together, this metabolic–epigenetic circuitry fuels sustained cancer cell proliferation

mTORC2 Driven Metabolic-Epigenetic Rewiring of Gangliosides Promotes Breast Cancer Progression

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