Dr. Prasenjit Guchhait
Professor
  • PhD, Banaras Hindu University
  • Postdoc at Baylor College of Medicine, USA
  • Instructor at Baylor College of Medicine, USA
  • Assistant Professor at Baylor College of Medicine, USA
  • Associate Professor at Regional Centre for Biotechnology, India
prasenjit[at]rcb[dot]res[dot]in

Disease Biology Laboratory

Major Focus:

  • Investigating Signaling Pathways of Thrombosis, Inflammation and Innate/Adaptive Immune Responses in Human Diseases including Viral Infections to Polymorphism Associated Pathogenesis.

  • Identifying Biomarkers and Molecular Targets 

  • Developing vaccine and anti-viral Therapeutics.

Host immune response in dengue virus (DENV) infection 

  • Investigating the pro-viral role of platelet factor 4 (PF4 or CXCL4) in DENV and JEV infection.

  • Developing and testing small molecule and monoclonal antibody against DENV in mice and non-human primate (NHP) models.

  • Identifying biomarkers of DENV severity.

  • Related pub:Gaur K et al. 2024 EMBO Molecular Medicine; Singh A et al. 2023 Journal of Thrombosis and Haemostasis; Singh A et al. 2023 Cytokine; Ojha A et al. 2019 EBioMedicine.

Host immune response in SARS-CoV-2 infection 

  • Molecular signaling of epithelial to mesenchymal transition (EMT) signaling and lung fibrosis in Long-COVID.

  • Developing and testing anti-viral drugs against SARS-CoV-2 infection in mice/hamsters. 

  • Related pub:Joshi G et al. 2025 Clinical and Translation Medicine; Agarwal S et al. 2022 Clinical and Translation Medicine; Shrimali NM et al. 2021 EBioMedicine. 

Host immune response in Chikungunya virus (CHIKV) and human papilloma virus (HPV) infection

  • Investigating the role of macrophage and T cell in CHIKV infection.

  • Investigating the role of antibody glycosylation in HPV vaccine efficacy.

 

Viral infections in diabetes

  • Severity of SARS-CoV-2 infection in type 1 diabetes (T1D)/ type 2 diabetes (T2D).

  • Severity of DENV infection in T1D/T2D.

  • Severity of CHIKV infection in T1D/T2D.

  • Related pub:Agarwal S et al. 2023 FEBS Journal; Agarwal S et al. 2023 Clinical Experimental Immunology.

Genetic polymorphism of Tibetan highlanders

  • Tibetan highlanders carrying PHD2D4E;C127S polymorphisms are protected from polycythemia and inflammation, on the other hand, non-Tibetan travelers from sea level to high altitudes are predisposed to mountain maladies like pulmonary and cerebral edema: Understanding the role of PHD2, HIF1α and Akt signaling. 

  • Tibetans carrying PHD2D4E;C127S polymorphisms are protected from viral infections.

  • Related pub:Ghosh R et al. 2025 PLOS Pathogens; Shrimali NM et al. 2025 Thrombosis and Haemostasis; Bhattacharya S et al. 2021 EBioMedicine; Shrimali NM et al. 2021 EBioMedicine.

Genetic polymorphism of Mappila children   

  • Lethal Aortopathy syndrome associated with novel FBLN4D203A Mutation among Mappila Children of seeking novel clinical, molecular genetic and anthropological insights. 

Genetic polymorphism of Kashmiri

  • Understanding the polymorphism associated with thrombocytopenia among certain Kashmiri population.

Hemolytic disorders 

  • Thrombosis and inflammation in hemolytic disorders including paroxysmal nocturnal hemoglobinuria (PNH) and sickle cell disease (SCD.

  • Related pub:Singhal R et al. 2015 Haematologica; Singhal R et al. 2016 Clinical Immunology; Singhal R et al. 2018 Euro J Immunology; Singhal R et al. 2019 Journal Immunology Research; Bhasym A et al. 2019 Clinical Experimental Immunology.

Autoimmune disorders 

  • Systemic inflammation in autoimmune disorders like atypical hemolytic uremic syndrome (aHUS) and systemic lupus erythematosus (SLE).

  • Related pub:Bhasym A et al. 2019 Journal of Clinical Immunology

 

  • Garima Joshi

    Senior Research Fellow

  • Garima Verma

    Senior Research Fellow

  • Tejeswara Rao Asuru

    Senior Research Fellow

  • Shalu Singh

    Senior Research Fellow

  • Md. Sahil

    Junior Research Fellow

  • Anupam Chawla

    Junior Research Fellow

  • Sakshi Mandal

    Junior Research Fellow

  • Anupama

    Ms-PhD Student

  • Richa Kumari

    Junior Research Fellow-Project

  • Shahira Sadaf

    Junior Research Fellow-Project

  • Guchhait Prasenjit and Asthana Shailendra (June’ 2023) anti-viral small molecule against dengue. Reference number 202011005513. Jointly, Regional Centre for Biotechnology (RCB), Faridabad, India, and Translational Health Science Technology Institute (THSTI), Faridabad, India.
     

Selected Publications

  1. Ghosh R, Joshi G, Shrimali NM, Bhardwaj K, Chorol T, Thinlas T, Koul PA, Prchal JT, Guchhait P*. (2025) Tibetan PHD2D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIFα:IFN axis. PLOS Pathogens 21(6): e1013296. https://doi.org/10.1371/journal.ppat.1013296

  2. Joshi G, Verma G, Kaur S, Ramasamy E, Chauhan N, Singh S, Jana P, Rizvi ZA, Kshetrapal P, Bhatnagar S, Pandey AK, Awasthi A, Das B, Guchhait P* (2025) Severe SARS-CoV-2 infection in diabetes was rescued in mice supplemented with metformin and αKG, and patients taking metformin, via HIF1α-IFN axis. Clinical and Translational Medicine https://doi.org/10.1002/ctm2.70275

  3. Gaur KK, Asuru TR, Srivastava M, Singh N, Purushotham N, Poojary B, Das B, Bhattacharyya S, Asthana S, Guchhait P* (2024) 7D, a small molecule inhibits dengue infection by increasing interferons and neutralizing-antibodies via CXCL4:CXCR3:p38:IRF3 and Sirt1:STAT3 axes respectively. EMBO Molecular Medicine https://doi.org/10.1038/s44321-024-00137-8.

  4. Shrimali NM, Agarwal S, Kaur S, Bhattacharya S, Bhattacharyya S, Prchal JT, Guchhait P* (2021) aKG inhibits thrombosis and inflammation by prolyl hydroxylase-2 mediated inactivation of phospho-Akt. EBioMedicine 73:103672.

  5. Bhattacharya S, Shrimali NM, Mohammad G, Koul PA, Prchal JT and Guchhait P*. (2021) Gain-of-function Tibetan PHD2D4E;C127S variant suppresses monocyte function: a lesson in inflammatory response to inspired hypoxia. EBioMedicine 68:103418.

  6. Ojha A, Bhasym A, Mukherjee S, Annarapu GK, Bhakuni T, Akbar I, Seth T, Vikram NK, Vrati S, Basu A, Bhattacharyya S, Guchhait P* (2019) Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses. EBioMedicine, 39: 332-347

  7. Singhal R, Annarapu GK, Pandey A, Chawla S, Ojha A, Gupta A, Cruz MA, Seth T, Guchhait P* (2015) Hemoglobin interaction with GP1b-alpha induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis. Haematologica 100(12): 1526-33. 

  8. Da Q, Teruya M, Guchhait P, Teruya J, Olson JS, Cruz MA*. (2015) Free hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications on circulatory devices. Blood. 126(20):2338-41. 

  9. Lorenzo LR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuran T, Li GR, McClain DL, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin Jr WG, Koivunen P & Prchal JT* (2014) A genetic mechanism for Tibetan high-altitude adaptation. Nature Genetics, 46:951-956. 

All Publications

  1. Jakhar K, Sonar S, Singh G, Asuru TR, Joshi G, Sarkar T, Tiwari M, Kaur J, Rathore DK, Lal B, Kumar S, Srivastav P, Kumar S, Phagna V, Kumar L, Vishal G, Kshetrapal P, Singh S, Wadhwa N, Thiruvengadam R, Raghavan S, Gosain M, Shrivastava T, Bhattacharyya S, Asthana S, Guchhait P, Mani S* (2026) SARS-CoV-2 Antibodies cross-reacts and Enhance Dengue Virus Infection In-Vitro and In-Vivo. Frontiers in Immunology doi: 10.3389/fimmu.2025.1724625

  2. Thakur S, Ghosh R, Chauhan N, Guchhait P, Eswaran SV (2026) The synthesis and anticancer activity of the Trastuzumab-Doxorubicin antibody-drug conjugate promoted alkyne-azide coupling. ACS Omega https://doi.org/10.1021/acsomega.5c02429

  3. Singh ON, Berry U, Joshi G, Asuru TR, Chandrasekar K, Narayanan S, Srivastava P, Mahima, Chattopadhyay S, Mehdi F, Panda BN, Nayak D, Mani S, Shrivastava T, Batra G, Ranjith-Kumar CT, Guchhait P, Surjit M* (2025) Comparison of immunogenicity and protection efficacy of self-amplifying and circular mRNA vaccines against SARS-CoV-2. iScience 28: 113498.

  4. Ghosh R, Joshi G, Shrimali NM, Bhardwaj K, Chorol T, Thinlas T, Koul PA, Prchal JT, Guchhait P*. (2025) Tibetan PHD2D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIFα:IFN axis. PLOS Pathogens 21(6): e1013296. https://doi.org/10.1371/journal.ppat.1013296

  5. Shrimali NM, Ghosh R, Bhardwaj K, Chorol T, Thinlas T, Koul PA, Prchal JT, Guchhait P*. (2025) Elevated protein S supports protection against hypoxia-induced hypercoagulation in Tibetan highlanders with PHD2D4E;C127S polymorphisms. Thrombosis and Haemostasis DOI: 10.1055/a-2580-0107.

  6. Thakur SK, Ghosh R, Guchhait P, Eswaran SV* (2025) Anti-Cancer Active Nano Carbon Drug Conjugate based on an Aryl Azide using the Classical ‘Click’ Chemistry. Nanomedicine Journal DOI: 10.22038/nmj.2025.80781.1998

  7. Joshi G, Verma G, Kaur S, Ramasamy E, Chauhan N, Singh S, Jana P, Rizvi ZA, Kshetrapal P, Bhatnagar S, Pandey AK, Awasthi A, Das B, Guchhait P* (2025) Severe SARS-CoV-2 infection in diabetes was rescued in mice supplemented with metformin and αKG, and patients taking metformin, via HIF1α-IFN axis. Clinical and Translational Medicine https://doi.org/10.1002/ctm2.70275

  8. Asuru TR, Rajagopal RE, Rejendran A, Parveen G, Das A, Devi P, Dasgupta S, Kalyanaraman, Guchhait P*, Thiagarajan P*. (2025) Identification of Cobra and Viper bites in Southern India using ELISA. Laboratory Medicine doi.org/10.1093/labmed/lmae119 

  9. Gaur KK, Asuru TR, Srivastava M, Singh N, Purushotham N, Poojary B, Das B, Bhattacharyya S, Asthana S*, Guchhait P* (2024) 7D, a small molecule inhibits dengue infection by increasing interferons and neutralizing-antibodies via CXCL4:CXCR3:p38:IRF3 and Sirt1:STAT3 axes respectively. EMBO Molecular Medicine https://doi.org/10.1038/s44321-024-00137-8.

  10. Singh A, Ghosh R, Asuru TR, Prajapat S, Joshi G, Gaur KK, Shrimali NM, Ojha A, Vikram NK, Poncz M, Kalia M, Guchhait P* (2023) Inhibition of platelet factor 4:CXCR3 pathway prevents JEV and DENV infection. Journal of Thrombosis and Haemostasis, 22:3:818-833 doi.org/10.1016/j.jtha.2023.11.015.

  11. Agarwal S, Saha S, Ghosh R, Sarmadhikari S, Asthana S, Maiti TK, Khadgawat R, Guchhait P* (2023) Elevated glycosylation of CD36 in platelets is a risk factor for oxLDL mediated platelet activation in type 2 diabetes. FEBS Journal, https://doi.org/10.1111/febs.16976

  12. Singh A, Ghosh R, Guchhait P* (2023) CXCR3 antagonist rescues ER stress and reduces inflammation and JEV infection in mice brain. Cytokine, 7:172:156380. 10.1016/j.cyto.2023.156380

  13. Agarwal S, Ghosh R, Verma G, Khadgawat R, Guchhait P* (2023) Alpha-ketoglutarate supplementation reduces inflammation and thrombosis in type 2 diabetes by suppressing leukocytes and platelet activation. Clinical and Experimental Immunology, https://doi.org/10.1093/cei/uxad086.

  14. Kumari Sharda, Bandyopadhyay Bhaswati, Singh Anamika, Aggarwal Suruchi, Yadav Amit, Vikram Naval, Guchhait Prasenjit and Banerjee Arup (2023) Extracellular vesicles recovered from plasma of severe dengue patients induced CD4+T cell suppression through PD-L1/PD1 interaction. mBIO (accepted).

  15. Gupta A, Sood A, Bhardwaj D, Shrimali N, Singhmar R, Chaturvedi S, Guchhait P, Agrawal G* (2023) Functionalized Chitosan Decorated Hafnium Oxide@Gold Core-Shell Nanoparticles for Multimodal Cancer Therapy. Advanced Therapeutics (accepted).

  16. Agarwal S, Kaur S, Asuru TR, Joshi G, Shrimali NM, Singh A, Singh ON, Srivastva P, Shrivastava T, Vrati S, Surjit M, Guchhait P* (2022) Dietary αKG inhibits SARS CoV-2 infection and rescues inflamed lungs to restore normal O2 saturation by inhibiting pAkt. Clinical and Translational Medicine e1041,12(9):1-6.

  17. Gupta A, Sood A, Dhiman A, Shrimali N, Singhmar R, Guchhait P, Agarwal G*. (2022) Redox Responsive Poly(allylamine)/Eudragit S-100 Nanoparticles for Dual Drug Delivery in Colorectal Cancer. Biomaterials Advances 143:e213184.  

  18. Thakur SK, Ghosh R, Gaur KK, Guchhait P, Eswaran SV* (2022) Anti-cancer activity of water-soluble reduced Graphene oxide-aryl arizidino manganese II complex. J Biomedical Nanotechnology 18:1-8.

  19. Mohanbhai SJ, Sardoiwala MN, Gupta S, Shrimali NM, Roy Choudhury S, Sharma SS, Guchhait P, Karmakar S* (2022) Colon targeted chitosan-melatonin nanotherapy for preclinical inflammatory bowel disease. Biomaterials advances 136:e212796.

  20. Gautam D, Kailashiya J, Tiwari A, Chaurasia RN, Annarapu GK, Guchhait P, Dash D* (2022) Fibrinogen mitigates prion-mediated platelet activation and neuronal cell toxicity. Frontiers Cell and developmental Biology, 10:e834016.

  21. Kaur S, Singh A, Kaur J, Verma N, Pandey AK, Das S, Bhattacharyya S, Guchhait P* (2022) Upregulation of cytokine signaling in platelet increases risk of thrombophilia in severe COVID-19 patients. Blood Cells Molecules and Diseases, 94:102653.  

  22. Chaudhury N, Srivastava S, Dave U, Ojha A, Guchhait P, Chandele A, Patel AK*. (2022). High-mobility group box 1 protein promotes dengue virus replication by interacting with untranslated regions of viral genome. Virus Research, 309:198668.

  23. Shrimali NM, Agarwal S, Kaur S, Bhattacharya S, Bhattacharyya S, Prchal JT, Guchhait P* (2021) aKG inhibits thrombosis and inflammation by prolyl hydroxylase-2 mediated inactivation of phospho-Akt. EBioMedicine 73:103672.

  24. Bhattacharya S, Shrimali NM, Mohammad G, Koul PA, Prchal JT and Guchhait P*. (2021) Gain-of-function Tibetan PHD2D4E;C127S variant suppresses monocyte function: a lesson in inflammatory response to inspired hypoxia. EBioMedicine 68:103418.

  25. Srivastava S, Chaudhary N, Ojha A, Guchhait P, Patel AK*. (2021) Signal transducer and activator of transcription 3 (STAT3) acts as a proviral factor for dengue virus propagation. Virus Research 300:198436.

  26. Thakur S, Saha S, Guchhait P, Eswaran S*. (2020) Fullarazirman, nano water-soluble Fullerene C60-Mn (II) Triadduct complex with anti-cancer activity comparable to Doxorubicin. J Biomedical Nanotechnology. 16:481-491.

  27. Thakur S, Goswami K, Rao P, Kaushik S, Singh B, Sharma PK, Asthana S, Bhattacharjee S, Guchhait P, Eswaran S*. (2020) A Fluoresceinated Aminohexanol Tethered Inositol Hexakisphosphate: Studies on Arabidopsis thaliana, Drosophila melanogaster and docking with 2P1M receptor. ACS Omega, 0c00961. 

  28. Sardoiwala N M, Kushwaha A, Dev A, Nishith S, Guchhait P, Karmakar S, Roy Choudhury S*. (2020) Hypericin loaded transferrin nanoparticles induce PP2A regulated BMI1 degradation in colorectal cancer specific chemo-Photodynamic Therapy. ACS Biomaterials Science & Engineering, 6,5, 3139-3153.

  29. Sood A, Dev A, Mohanbhai SJ, Shrimali N, Kapasiya M, Kushwaha A, Choudhury SR, Guchhait P, Karmakar S* (2019) Development and targeting efficacy of disulfide bridged chitosan-Eudragit S-100 nanoparticles for colorectal cancer, ACS Applied Nano Materials. 2, 10: 6409-17.

  30. Thakur S, Goswami K, Bhattacharjee S, Soni U, Guchhait P, Eswaran S*. (2019) A Water Soluble Single Walled Carbon Nanotube Aryl Aziridino Carboxylic Acid Decorated Mn (II) Complex Increased Root Growth in Arabidopsis thaliana. Chemistry Select. 201904205.

  31. Bhasym A, Bhakuni T and Guchhait P* (2019) Elevated surface-bound complement factor-H alters the function of platelets and monocytes in FHR1/3-null healthy individuals. Blood Cells Molecules Diseases, 79:102349.

  32. Bhasym A, Annarapu GK, Saha S, Shrimali NM, Gupta S, Seth T, Guchhait P*. (2019) Neutrophils develop rapid proinflammatory response after engulfing Hb-activated platelets under intravascular hemolysis. Clinical and Experimental Immunology, doi: 10.1111/cei.13310

  33. Bhakuni T, Singhal R, Aannarapu GK, Sharma A, Mahapatra M, Saxena R, Guchhait P* (2019) Unique case of autoantibody mediated inactivation of ADAMTS13 in an Indian TTP patient. Blood Cells Molecules Diseases, 77:29-33

  34. Bhasym A, Gurjar BS, Sriharsha TM, Prabhu S, Puraswani M, Khandelwal P, Saini H, Saini S, Verma AK, Chatterjee P, Bal V, George A, Sharma A, Hari P, Sinha A, Bagga A, Rath S, Guchhait P* (2019) Altered Peripheral Blood Leucocyte Phenotype and Responses in Healthy Individuals with Homozygous Deletion of FHR1 and FHR3 Gene. Journal of Clinical Immunology, doi.org/10.1007/s10875-019-00619-2

  35. R Singhal, DK Rathore, T Bhakuni, T Seth, P Guchhait* (2019) Absence of Non-classical Monocytes in Hemolytic Patients: Free Hb and NO-Mediated Mechanism. Journal of Immunology Research, doi.org/10.1155/2019/1409383

  36. Ojha A, Bhasym A, Mukherjee S, Annarapu GK, Bhakuni T, Akbar I, Seth T, Vikram NK, Vrati S, Basu A, Bhattacharyya S, Guchhait P* (2019) Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses. EBioMedicine, 39: 332-347

  37. Singhal R, Chawla S, Batra H, Gupta S, Ojha A, Rathore DK, Seth T and Guchhait P*. (2018) Engulfment of Hb-activated platelets differentiates monocytes into pro-inflammatory macrophages in PNH patients. European J Immunology. 48(8):1285-1294 doi: 10.1002/eji.201747449.

  38. Gurjar BS, Sriharsha TM, Bhasym A, Prabhu S, Puraswani M, Khandelwal P, Saini H, Saini S, Verma AK, Chatterjee P, Guchhait P, Bal V, George A, Rath S, Sahu A, Sharma A, Hari P, Sinha A, Bagga A. (2018) Characterization of genetic predisposition and autoantibody profile in atypical hemolytic uremic syndrome. Immunology. 154, 663-672. doi: 10.1111/imm.12916.

  39. Ojha A, Nandi D, Batra H, Singhal R, Annarapu GK, Bhattacharyya S, Seth T, Dar L, Medigeshi GR, Vrati S, Vikram NK, Guchhait P*. (2017) Platelet activation determines the severity of thrombocytopenia in dengue infection. Scientific Reports, 7:41697. 

  40. Tashi T, Reading NS, Moore LG, Wuren T, Hu H, Teng F, Shestakova A, Lorenzo F, Burjanivova T, Koul P, Guchhait P, Wittwer C, Julian CG, Shah B, Huff CD, Ge R, Gordeuk VR, Prchal JT*. (2017) Gain-of-Function EGLN1 Prolyl Hydroxylase (PHD2 D4E:C127S) in Combination with EPAS1 (HIF2α) Polymorphism Lowers Hemoglobin Concentration in Tibetans. Journal of Molecular Medicine, p1-6. 

  41. Singhal R, Chawla S, Rathore D, Bhasym A, Annarapu GK, Sharma V, Seth T, Guchhait P*. (2016) Development of pro-inflammatory phenotype in monocytes after engulfing Hb-activated platelets in hemolytic disorders. Clinical Immunology, doi:10.1016/ j.clim.2016.12.007. 

  42. Annarapu GK, Singhal R,Gupta A, Chawla S, Batra H, Seth T, and Guchhait P*. (2016) HbS binding to GP1bα activates platelets in sickle cell disease. PLoS One, 11(12): e0167899. doi:10.1371/journal. 

  43. Annarapu GK, Singhal R, Peng Y, Guchhait P*. (2016) Inhibition of Hb binding to GP1bα abrogates Hb-mediated thrombus formation on immobilized VWF and collagen under physiological shear stress. PLoS One, 11(4):e0154276. 

  44. Singhal R, Annarapu GK, Pandey A, Chawla S, Ojha A, Gupta A, Cruz MA, Seth T, Guchhait P*. (2015) Hemoglobin interaction with GP1balpha induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis. Haematologica 100(12): 1526-33. 

  45. Da Q, Teruya M, Guchhait P, Teruya J, Olson JS, Cruz MA*. (2015) Free hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications on circulatory devices. Blood. 126(20):2338-41. 

  46. Lorenzo LR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuran T, Li GR, McClain DL, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin Jr WG, Koivunen P & Prchal JT*. (2014) A genetic mechanism for Tibetan high-altitude adaptation. Nature Genetics, 46:951-956. 

  47. Zhou Z, Thiagarajan P, Udden MA, Lopez JA, Guchhait P*. (2011) Membrane sulfatide plays a crucial role in the sickle erythrocytes adhesion to matrix and endothelial ligands. Thrombosis Haemostasis. 105:1046-52. 

  48. Zhou Z, Han H, Cruz MA, Jose JA, Dong JF, Guchhait P*. (2009) Hemoglobin blocks von Willebrand factor proteolysis by ADAMTS-13: a mechanism associated with sickle cell disease. Thrombosis Haemostasis, 101 (6): 1070-77. 

  49. Guchhait P*, Shrimpton C, Honke K, Rumbaut R, Lopez JA, Thiagarajan P. (2008) Effects of an anti-sulfatide single-chain antibody probe on platelet function. Thrombosis Haemostasis, 99(3):552-57. 

  50. Dasgupta SK, Abdel-Monem H, Guchhait P, Nagata S, Thiagarajan P*. (2008) Role of lactadherin in the clearance of phosphatidylserine-expressing red blood cell in sickle cell disease. Transfusion, 48(11):2370-76.

  51. Guchhait P, Dasgupta SK, Le A, Yellapragada S, Lopez JA, Thiagarajan P*. (2007) Lactadherin mediates sickle cell adhesion to the vascular endothelial cells in flowing blood. Hematologica, 92(9):1266-67.  

  52. Dasgupta SK, Guchhait P, Thiagarajan P*. (2006) Lactadherin binding and phosphatidylserine expression on cell surface-comparison with annexin A5. Translational Research, 148:19-25. 

  53. Lasser G, Guchhait P, Ellsworth J, Bishop P, Cruz MA, Lopez JA, Fruebis J*. (2006) C1q-TNF related protein-1 (CTRP-1), a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen. Blood, 107:423-430. 

  54. Guchhait P, Lopez JA, Thiagarajan P*. (2004) Characterization of autoantibodies against sulfatide from a V-gene phage-display library derived from patients with systemic lupus erythematosus. J. Immunol. Methods, 295: 129–137. 

  55. Bernardo A, Bergeron AL, Sun CW, Guchhait P, Cruz MA, Lopez JA, Dong JF*. (2004) Von Willebrand factor present in fibrillar collagen enhances platelet adhesion to collagen and collagen-induced platelet aggregation. J. Thromb. Haemost. 2(4): 660-9. 

  56. Guchhait P, Tosi MF, Smith CW, Chakraborty A*. (2003) The murine myeloid cell line 32Dcl3 as a model system for studying neutrophil functions. J. Immunol. Methods. 283(1-2): 195-204. 

 

Review Articles

 

  1. Bhardwaj K, Ranjith-Kumar CT, Guchhait P and Vrati S (2026) "Current Perspectives on Alphavirus Encapsidation, Assembly and Budding" Frontiers in Cellular and Infection Microbiology   https://doi.org/10.3389/fcimb.2025.1719868

  2. Chauhan N, Gaur KK, Asuru TR, Guchhait P* (2024) Dengue virus: pathogenesis and potential small molecule antivirals. Bioscience Reports, 44 BSR20240134; https://doi.org/10.1042/BSR20240134 

  3. Joshi G, Das A, Verma G, Guchhait P* (2023) Viral infection and host immune response in diabetes. IUBMB Life, DOI: 10.1002/iub.2794.

  4. Shrimali MN, Agarwal S, Tiwari A, Guchhait P* (2022) Platelet-Neutrophil interactions and thrombo-inflammatory complications in type-2 diabetes mellitus. Current Physiology Reports, 10:1-10.

  5. Bhattacharya S, Agarwal S, Shrimali SM and Guchhait P* (2021) Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases. Molecular Aspects of Medicine. 81:101000

  6. Singh A, Bisht P, Bhattacharya S, Guchhait P*. (2020) Role of platelet cytokines in Dengue virus infection. Frontiers in Cellular and Infection Microbiology, 10:561366

  7. Batra H, Chawla S, Singhal R, Annarapu GK, Guchhait P*.  (2016) Cell free hemoglobin modulates phenotype and function of immune cells in hemolytic disorders. Austin Hematology, 1(1): 1007. 

  8. Bhattacharya S, Bhasym A, Guchhait P*. (2016) Insights into Cardiovascular Diseases: The Vicious Platelet-Immune System Loop. Cardiology: Open Access, 1(1):1-7.

  9. Annarapu GK, Singhal R, Chawla S, Ojha A, Guchhait P*. (2016) Hemoglobin mediated regulation of platelet functions. Journal of Hematology and Transfusion, 4(3): 1052.

  10. Pandey A, Chawla S, Guchhait P*. (2015) Type-2 diabetes: Current understanding and future perspectives. IUBMB Life. 67:506.

  11. Chawla S., Singhal R., Guchhait P*. (2014) Hypertension in hypoxia. Hypertension Cardiol. 1 (3): 1-16. 

  12. Zhou Z, Yee D, Guchhait P*. (2012) Molecular link between intravascular hemolysis and vascular occlusion in sickle cell disease. Current Vascular Pharmacology. 10(6):756-61. 

  13. Zhou Z, Behymer M, Guchhait P*. (2011) Role of extracellular hemoglobin in thrombosis and vascular occlusion in patients with sickle cell anemia. Anemia. 10.1155/2011/918916. 

  14. Zhou Zhou, Prasenjit Guchhait*. (2010) Extracellular Hemoglobin regulation of von Willebrand factor activity. US Oncology & Hematology, 7(2):150–2. 

  15. Zhou Z*, Nguyen T, Guchhait P, Dong JF*. (2010) Von Willebrand factor, ADAMTS-13, and Thrombotic thrombocytopenic purpura. Seminar in Thrombosis Hemostasis, 36:71-81. 

     Book Chapters

 

  1. Bhardwaj K*, Ranjith-Kumar CT, Guchhait P, Vrati S (2025) Viral Zoonoses: Pathways and Mechanisms. IntechOpen book "Current Topics in Viral Outbreaks". https://www.intechopen.com/online-first/1211750

  2. Tiwari RL, Annarapu GK, Guchhait P*. (2013) Pathophysiological consequences of hemolysis in sickle cell disease in "Sickle Cell Disease" (Ed. D Acuna-Costroviejo and I Rusanova). Nova Science Publishers, Inc. ISBN: 978-1-62618-774-0.

 

Patent application 

  • Guchhait Prasenjit and Thiagarajan Perumal (March 2026) Developing neutralizing monoclonal antibody against venom toxins of major Indian snakes and its diagnostic and therapeutic applications. Indian Patent Reference number 202611036952. Regional Centre for Biotechnology, Faridabad, India and Baylor College of Medicine, Houston, USA filed this patent. Area of patent ~ Public health; TLR level ~ 4/5.

  • Guchhait Prasenjit and Asthana Shailendra (June’ 2025) 1,2-Disubstituted benzimidazolyl amino acids, namely 7D, which inhibits flaviviruses infection. Indian Parent Reference number 202011005513. Translational Health Science Technology Institute, Faridabad, India; and Regional Centre for Biotechnology, Faridabad, India filed this patent jointly. Area of patent ~ Public health; TLR level ~ 4/5.

  • Guchhait Prasenjit, Eswaran S V (May’ 2022) Anti-Cancer Activity of a new Water-soluble Reduced Graphene Oxide- Manganese (II) Complex Against Three Human Cancer Cell lines. Registration Number 202211032025. From the Regional Centre for Biotechnology, Faridabad, India. Area of patent ~ Public health; TLR level ~ 3.

  • Guchhait Prasenjit, Eswaran S V (June’ 2019) Water Soluble Fullerene C60 Adducts for Nano-Medicine & Materials Science; Application/ Registration Number   201811020894. From the Regional Centre for Biotechnology, Faridabad, India. Area of patent ~ Public health; TLR level ~ 3.

  1. Follow of National Academy (FNA), India
  2. Doctor of Science (D.Sc.), Banaras Hindu University, India
Dr. Prasenjit Guchhait
Professor

Regional Centre for Biotechnology
NCR Biotech Science Cluster
3rd Milestone, Faridabad-Gurgaon Expressway
P.O. Box No. 3, Faridabad - 121 001
Haryana (NCR Delhi), India
E-mail: prasenjit at rcb dot res dot in
Phone: 91 129-2848821

no text prasenjit[at]rcb[dot]res[dot]in
no text 91 129-2848821

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